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The dosage of protamin need to increased to 3 mg/kg as the heparin is over 400 U/kg before CPB in the patients with IE, but the ratio of protamin and heparin will not be obviously changed. IE病人轉流前肝素用量大於400U/kg,魚精蛋白用量需增加至3mg/kg,而魚精蛋白與肝素之比無明顯變化。